先端科学のための実践生物学IIB【220003】


Basic course information

Course type 基礎 Credits 1
Elective/Compulsory 必修 Course format 講義
Course start 5月12日～7月21日 Room 大セミナー室　C109

Course outline

Supervising lecturer 駒井
Lecturer 駒井、伊東、橋本、加藤順、磯谷、河合、末次
Course objectives 細胞生物学の重要な概念を実践的なトピックを題材にして学び、バイオサイエンス研究を広い視野で遂行するスキルを養う。重要な生命現象そのものだけでなく、それらが発見・証明された研究の過程や、実際の研究例について学ぶ。さらに、実験データの解析のために統計学を学ぶ。
The aims of this course are to understand important concepts in cellular biology through practical biological achievements, and cultivate wide knowledge and skill, which are essential for biological research. The course introduces the processes of the achievements that uncovered important life phenomena. In addition, the course deals with biological statistics for analyses of experimental data.
Course methodology 生命現象の理解につながった実践的な研究のトピックスを例として取り上げ、学生のバイオサイエンス研究を活性化する講義を行う。
This course introduces previous research topics that uncover the cellular mechanisms, and encourges the researches that students are tackling.

Course plan

Comments Number Topic Content
1 【B-13】生殖と遺伝学Reproduction and Genetics (磯谷)多細胞生物は次世代の個体を生殖によって作り出す。有性生殖とその過程で起こる減数分裂について学ぶ。また有性生殖の遺伝学を学び、ヒトの疾患の分子レベルでの解明の手法を理解する。 Essential細胞生物学19章を予習、復習すること。 (Isotani) Multicellular Organisms reproduce their ofsprings by reproduction. The aim of this class is to understand sexual reproduction and meiosis. This class also deals with genetics of sexual reproduction and genetic analyses, which enable to understand molecular basis of human disease. Students must read Chapter 19 before the class, and must review what they learned.
2 【B-10】細胞の情報伝達
Cell Communication		 (伊東)細胞におけるシグナル伝達の仕組みを分子レベルで理解する。シグナル伝達に関わる分子の構造と機能を基本概念と伴に学ぶ。
Essential細胞生物学16章を予習、復習すること。
(Itoh) The aim of this class is to understand the mechanisms of cellular signal transduction in molecular levels. Students learn structure and function of signal transducing molecules involved in cell communication with basic concepts.
Students must read Chapter 16 before the class, and must review what they learned.
3 【A-9】膜の構造と膜輸送Membrane Structure and Membrane Transport (駒井)先端科学のための実践生物学A-9で学んだ膜の構造と膜輸送について、グループで協力して概念図を作成する。また、グループで協力して演習問題を解き、発表する。
(Komai) Each group clarifies what students learned for Membrane Structure and Membrane Transport in Practical Biology for Advanced ScienceA-9, generates a concept figure, solves exerscises, and makes presentation in collaboration with one another
4 【B-12】細胞周期
The Cell Division Cycle		 (加藤順)細胞は、細胞分裂によって細胞から生じる。サイクリンとCDKの機能を分子レベルで理解して、細胞周期と細胞分裂の基本概念を学ぶ。また細胞死について理解する。
Essential細胞生物学18章を予習、復習すること。
(Kato) The only way to make more cells is by the division of those that already exist. The aim of this class is to understand molecular basis of the cell cycle and cell division, in which cyclins and CDKs play critical roles. This class also deals with cell death.
Students must read Chapter 18 before the class, and must review what they learned.
5 【B-11】細胞骨格Cytoskeleton (橋本)細胞骨格の基礎を理解して、細胞内輸送や細胞運動における細胞骨格の動的な機能を学ぶ。 Essential細胞生物学17章を予習、復習すること。 (Hashimoto) The aim of this class is to understand the molecular basis of cytoskeleton. This class also deals with dynamism of cytoskeleton in intracellular transport and cellular movement. Students must read Chapter 17 before the class, and must review what they learned.
6 【B-15】統計
Statistics in Bioscience 1		 (末次)統計学の基本的な概念・手法及びその生命科学研究への応用を学ぶ。
(Suetsugu) The aim of this class is to understand basic concept and method of statistics. This class also introduces the application of statistics to bioscience.
7 【B-16】統計学
Statistics in Bioscience 2		 (末次)統計学の基本的な概念・手法及びその生命科学研究への応用を学ぶ。
(Suetsugu) The aim of this class is to understand basic concept and method of statistics. This class also introduces the application of statistics to bioscience.
8 【B-14】幹細胞、発生とがん
Stem Cell, Development, and Cancer		 (河合)多細胞生物の組織が更新され修復されるときに幹細胞が担う役割を学ぶ。また幹細胞から組織や器官が分化する過程である発生を学び、細胞が変異を起こして、制御から逸脱する現象であるがんについて理解する。
Essential細胞生物学20章を予習、復習すること。
(Kawai) This class introduces the critical roles of stem cells during tissue renewal ane repairment in multicellular organisms.　This class also deals with development of tissues and organs, and cancer, in which cells are mutated and are out of control.
Students must read Chapter 20 before the class, and must review what they learned.
9 まとめとテスト
The Review and Examination		 学習した内容をまとめ、テストをおこなう。
In this class, we review what we learned in the course, and check the knowledge by examination.    

Textbook/Reference book

Textbook Essential細胞生物学原書第4版（南江堂）
Essential Cell Biology 4th edition (Garland Science)
Reference book 細胞の分子生物学、遺伝子の分子生物学
Molecular Biology of the Cell, Molecular Biology of the Gene

Other information

Eligibility for this course 2/3以上の回の出席を条件とする。
Students are required to attend a minimum of 2/3 of classes.
Consultation times 授業当日の3時限目。授業が3時限目の時は同日の4時限目。
Grades/Evaluation バイオゼミナール基礎IIと一括して評価する。
期末テスト50％、各回のミニテスト25％、概念図およびノート25％
Grading of this course will be decided together with that of Basic Bioscience Seminar I.
Term-end examination: 50%, Mini-examination in each class: 25%, Concept figure and note in each class: 25%.
Related courses バイオゼミナール基礎IIB
Basic Bioscience Seminar IIB　
Important information 日本語で行われます。
This will be taught in Japanese.