システムズバイオロジⅠ (130038)

担当教員 金谷 重彦(Shigehiko Kanaya / かなや しげひこ)、 MD. ALTAF-UL-AMIN
単位数 :1単位 選択・必修 :選択 講義室 :L2 講義スタイル :講義/公開
開講時期 Ⅰ期 火曜1限

授業目的 Introducing the basic concepts of Systems biology in the context of graph theory and algorithms and making familiar with some software tools related to systems biology.
授業内容 [1]Introduction to Graphs/Networks, Different network models, Properties of Protein-Protein Interaction Networks, Different centrality measures of nodes, Protein Function prediction using network concepts, Application of network concepts in DNA sequencing, Line graphs.
[2]Concept and types of metric, Hierarchical Clustering, Finding clusters in undirected simple graphs: application to protein complex detection.
[3]Introduction to KNApSAcK database, Metabolic Reaction system as ordinary differential equations, Metabolic Reaction system as stochastic process.
[4]Metabolic network and stoichiometric matrix, Information contained in stoichiometric matrix, Elementary flux modes and extreme pathways.
[5]Graph spectral analysis/Graph spectral clustering and its application to metabolic networks.
[6]Normalization procedures for gene expression data, Tests for differential expression of genes, Multiple testing and FDR, Reverse Engineering of genetic networks.
[7]Finding Biclusters in Bipartite Graphs, Properties of transcriptional/gene regulatory networks, Introduction to software package Expander.
[8]Introduction to signaling pathways, Selected biological processes: Glycolytic oscillations, sustained oscillation in signaling cascades.
[9]Structural Similarity based Multifaceted Analysis of Metabolites.

教科書 特に指定しない
Unspecific
参考書 特に指定しない
Unspecific
履修条件 特になし。
No prerequisites
成績評価 レポートと試験(50%)、出席(50%)の内容により成績を評価する。
Report and test (50%), attendance (50%)
オフィスアワー 在室しているときは原則的にいつでも可(B511:Md.Altuf-Ul-Amin)
anytime when available (B511: Md.Altuf-Ul-Amin)
配布資料 現在、配布資料はありません。