◇ 担当教員 : |
金谷 重彦(Shigehiko Kanaya / かなや しげひこ)、 MD. ALTAF-UL-AMIN |
◇ 単位数 :1単位 |
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◇ 選択・必修 :選択 |
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◇ 講義室 :L2 |
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◇ 講義スタイル :講義/公開 |
◇ 授業目的 : |
Introducing the basic concepts of Systems biology in the context of graph theory and algorithms and making familiar with some software tools related to systems biology. |
◇ 授業内容 : |
[1]Introduction to Graphs/Networks, Different network models, Properties of Protein-Protein Interaction Networks, Different centrality measures of nodes, Protein Function prediction using network concepts, Application of network concepts in DNA sequencing, Line graphs. [2]Concept and types of metric, Hierarchical Clustering, Finding clusters in undirected simple graphs: application to protein complex detection. [3]Introduction to KNApSAcK database, Metabolic Reaction system as ordinary differential equations, Metabolic Reaction system as stochastic process. [4]Metabolic network and stoichiometric matrix, Information contained in stoichiometric matrix, Elementary flux modes and extreme pathways. [5]Graph spectral analysis/Graph spectral clustering and its application to metabolic networks. [6]Normalization procedures for gene expression data, Tests for differential expression of genes, Multiple testing and FDR, Reverse Engineering of genetic networks. [7]Finding Biclusters in Bipartite Graphs, Properties of transcriptional/gene regulatory networks, Introduction to software package Expander. [8]Introduction to signaling pathways, Selected biological processes: Glycolytic oscillations, sustained oscillation in signaling cascades. [9]Structural Similarity based Multifaceted Analysis of Metabolites. |
◇ 教科書 : |
特に指定しない Unspecific |
◇ 参考書 : |
特に指定しない Unspecific |
◇ 履修条件 : |
特になし。 No prerequisites |
◇ 成績評価 : |
レポートと試験(50%)、出席(50%)の内容により成績を評価する。 Report and test (50%), attendance (50%) |
◇ オフィスアワー : |
在室しているときは原則的にいつでも可(B511:Md.Altuf-Ul-Amin) anytime when available (B511: Md.Altuf-Ul-Amin) |
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